Biaggio Pernice discoverer of chromosomal toxic abnormalities

BIAGGIO PERNICE DISCOVERER OF TOXIC CHROMOSOMAL ABERRATIONS

André J. Fabre                    2012.

 A little-known chapter in the history of medicine are the genetic studies done, at the end of nineteenth century; by a physician of the hospital in Palermo, Biaggio Pernice

 

A SUCCESSFULL RESEARCHER

 Pernice, , a rare case among scientists, financed his researches by himself :  in 1889 he demonstrated on dogs that the absorption of large doses of tincture of colchicum causes severe abnormalities in chromosomal mitosis, with a remarkable phenomenon of inhibition of metaphase.

Biaggio Pernice had published his results in a confidential medical journal of his time the "Sicilia Medica", entitled "Sulla cariocinesi della cell epiteliali dell'endotelio dei vasi e della mucosa dello stomaco e dell'intestino, nelle studio Sperimentale della gastroenteritis (nell'avvelenamento per colchico"[1].

Despite the considerable scope of discovery, this work would remain unknown until 1949, when they were exhumed by miracle in the Index Medicus, published by the National Library of Medicine of the United States which included, since 1879, the references worldwide.

Since 2004, the Index Medicus was replaced by Medline and Pubmed but the name Pernice is henceforth part of the History of Medicine: he was the first to demonstrate that a chemical may be responsible for impaired chromosomal capital.

 

A CURTAIN FALLING ON DISCOVERERS IN GENETICSCIENCES ?

 

Many other researchers, whose names are too often fallen into oblivion, took an active part in the discovery of the laws of genetics: three names come here in first place Johann Mendel, Walter Edward Strasburger and Flemming

 

JOHANN MENDEL (1822-1884): THE MONK FROM BRNO

While the name Johann Mendel [2] is always cited when it comes to genetics but who really knows what was his life? Monk from Brno, in 1865 he published an article entitled: Research on plant hybrids where exposing his views on genetics and heredity. Mendel had sent his work to the greatest experts in the field and only one of them replied ..

However, Mendel keep his life a very innovative mind sharing it, now we know all the liberal aspirations of his time but membership of a religious order who could give him the most favorable research required him conditions back, a reserve requirement.

 

EDWARD STRASBURGER 1844-1912) BOTANIST D'IENA

Edward Strasburger [3] had studied in Bonn and Paris and received his doctorate at the University of Jena in 1866. He began teaching at the University of Warsaw before becoming a professor of botany at Jena from 1869 to 1880 and then and for the rest of his life at the University of Bonn. It was he who first showed the existence of the phenomenon of chromatic reduction

 

WALTHER FLEMMING (1843-1905),  PRUSSIAN MILITARY DOCTOR

Walthe Flemming [4] was born in Sachsenberg in Mecklenburg. He became a military doctor during the Franco-Prussian War and then came in office at the University of Prague and Kiel. To him belongs the credit of having understood the first, the phenomena of mitotic chromosome where his colleagues saw only a single nuclear atypia. Everything is explained in a book dated 1882: "Substance cell nuclei and cell division." He left a phrase that should, in itself, ensure his fame: "Every cell comes from a preexisting cell"

 

In truth, it is likely that geneticists have been taken in the previous century, the Hades wonderful helmet, according to the ancients had the power to make invisibl

 

a.fabre.fl@gmail.com

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Date de dernière mise à jour : 18/07/2013

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